Organ Set Diablo's Horn, Baal's Eye & Mephisto's Brain. Cube all 3 in Harrogath (Act 5) on Hell to create a Red Portal to Uber Tristram where you'll fight the 3 Uber Prime Evils at once for the Hellfire Charm and Standard of Heroes. Be prepared. This is extremely difficult.
Rarity: White/Grey
Realm: East Non-Ladder